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METHADOSE is contraindicated in individuals with known or suspected gastrointestinal obstruction, like paralytic ileus. The methadone in METHADOSE may possibly lead to spasm of the sphincter of Oddi.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​â